In a bowl, combine first five ingredients; spoon into pie shell. For topping, combine sugar and flour; cut in butter until mixture resembles coarse crumbs. Sprinkle over pie. Bake at 400° for 10 minutes. Reduce heat to 375°; bake for 40-45 minutes or until the topping is browned and apples are tender. Cover crust edges with foil during the last 15 minutes if needed. Cool completely before cutting.